Jim Letourneau's Blog

Investing, Technology, Travel, Geology, Music, Golf. I think that covers it.

Importance of HDL Type

This post is part of 6 a 16 part series of posts taken from the transcript of an interview I (JL) conducted with Resverlogix (RVX.TO) co-founders Dr. Norman Wong (NW) and Donald McCaffrey (DM).

What follows is a lengthy and candid interview about the history of Resverlogix, recent events at the American Heart Association meetings, and future plans for the company.

I'll be publishing two interview segments a day so not all of the links may be active if you are viewing this near the end of March 28-April 5, 2011.

  1. Background of Dr. Norman Wong

  2. Early History of Resverlogix

  3. HDL Biology

  4. American Heart Association Meeting - 2010

  5. CETP History

  6. Importance of HDL Type

  7. AHA ASSERT Trial Response

  8. ALTs

  9. Investor Reaction

  10. The Next 2 Years

  11. David vs. Goliath

  12. Alzheimer's Therapy Potential

  13. Upcoming Assure Trial

  14. Volatility of Resverlogix

  15. Resverlogix is Expanding

  16. More on the sell-off

Part 6

So the alpha-1 HDL particle is the one that's now grown into the fully matured

plaque accepting particle. So for every one milligram per deciliter that you have of alpha-1
more than me, you have 26% less chance of cardiovascular disease.

Well, the AHA panel also neglected to note the fact that we have increased these important
particles by 4.2, not 1, 4.2 milligrams per deciliter. So 21% in the last trial is very successful
data for scientists who understand this process. For media, they don't get it, they're looking
at a numbers game. Their view is “what do you mean this low number versus that higher
number, and the little number's better? How does that work? They don't get it yet. They're
looking for quick snap headlines. We at RVX just have to keep pushing through, because
this drug works very well, and it's working on the right end of the HDL equation. Somebody
should snap this company up someday, because good data keeps pouring out.